Anastrozole: Generic, Uses, Side Effects, Dosages, Interactions, Warnings

Anastrozole: Generic, Uses, Side Effects, Dosages, Interactions, Warnings

Steady-state plasma levels are approximately 3-to 4-fold higher than levels observed after a single dose of ARIMIDEX. Plasma concentrations approach steady-state levels at about 7 days of once daily dosing. Anastrozole is 40% bound to plasma proteins in the therapeutic range. In postmenopausal women, estrogens are mainly derived from the action of the aromatase enzyme, which converts adrenal androgens (primarily androstenedione and testosterone) to estrone and estradiol.

In rabbits, anastrozole caused pregnancy failure at doses equal to or greater than 16 times the recommended human dose on a mg/m² basis [see Animal Toxicology and/or Pharmacology]. Clinical trials have been conducted with Anastrozole, up to 60 mg in a single dose given to healthy male volunteers and up to 10 mg daily given to postmenopausal women with advanced breast cancer; these dosages were tolerated. A single dose of Anastrozole that results in life-threatening symptoms has not been established. There is no specific antidote to overdosage and treatment must be symptomatic. In the management of an overdose, consider that multiple agents may have been taken. Dialysis may be helpful because Anastrozole is not highly protein bound.

Will I need to use this drug long term?

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  • In both studies there were no significant differences between treatment arms with respect to any of the efficacy parameters listed in the table below.
  • You may wonder how Arimidex compares with other medications that are prescribed for similar uses.
  • “The PROCAS research studies have shown that risk algorithms such as Tyrer-Cuzick and CanRisk are able to identify women at a significantly increased risk of breast cancer even when there is no family history of the disease.
  • Anastrozole is a medication used in the management and treatment of breast cancer.

Cuzick attributed the difference to patients dropping out of the anastrozole arm because of adverse events. It blocks the action of the aromatase enzyme, which then prevents the conversion of androgens into estrogen. In postmenopausal women, estrogen is primarily produced by the aromatase enzyme. Arimidex is approved to treat certain types of breast cancer in women who’ve gone through menopause.


This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to theFDA at FDA-1088. In postmenopausal women, the ovaries stop producing estrogens and the primary source of estrogens are those derived from the male sex hormones (androgens) androstenedione and testosterone produced by the adrenal gland. Aromatase is responsible for the conversion of the two androgens into estrone and estradiol. By inhibiting aromatase, anastrozole reduces the availability of estrogens that the cancer cells require to grow.

  • Patients should be informed that an increased level of cholesterol might be seen while receiving ARIMIDEX.
  • The decision to license this medication for prevention as well as treatment of breast cancer, has been made as part of a programme run by the MHRA to repurpose existing medication for different conditions.
  • Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet.
  • This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
  • For more information on the possible side effects of Arimidex, talk with your doctor or pharmacist.

The incidence of lymphosarcoma was increased in males and females at the high dose. At 50 mg/kg/day, plasma AUC levels in mice were 35 to 40 times higher than the level exhibited in postmenopausal volunteers at the recommended dose. Arimidex isn’t FDA-approved to treat breast cancer in premenopausal women. (Women who haven’t gone through menopause are called premenopausal.) But sometimes the drug is used off-label in this group of women to treat hormone receptor-positive (HR+) cancers. With HR+ breast cancer, the cancer is encouraged to grow by hormones.

Patients receiving ARIMIDEX had an increase in the incidence of all fractures (specifically fractures of spine, hip and wrist) [315 (10%)] compared with patients receiving tamoxifen [209 (7%)]. For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial, ARIMIDEX was administered for five years [see Clinical Studies]. The aromatase inhibitor anastrozole maintained a preventive effect for postmenopausal women at high risk for breast cancer nearly 12 years after discontinuing treatment. Anastrozole (Arimidex)is prescribed for post-surgical treatment of breast cancer in women who are postmenopausal.

Arimidex Images

It’s hard to say how long your side effects will last, as each person’s reaction to the drug can be different. How long you’ll have side effects from the drug depends on how your body reacts to Arimidex. The following lists contain some of the key side effects that may occur while taking Arimidex. And your side effects may vary from those listed below depending on the condition you’re using Arimidex to treat.

Anastrozole oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. There are two major contraindications to aromatase inhibitors.

Talk with your doctor about what kind of physical activity is right for you. They can also recommend how much activity you should try to do. If you have questions about your risk of reduced bone mineral density while you’re taking Arimidex, talk with your doctor.